Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 14, Issue 1, Pages 6-30Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201801237
Keywords
cross-coupling; dehydrogenation; green chemistry; iodine; organic transformations
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Funding
- National Institutes of Health (NIH) [GM097118, AI090662]
- NIH
- Kleberg Foundation
- National Cancer Institute (NCI)
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The development of ecofriendly methods for carbon-carbon (C-C) and carbon-heteroatom (C-Het) bond formation is of great significance in modern-day research. Metal-free cross-dehydrogenative coupling (CDC) has emerged as an important tool for organic and medicinal chemists as a means to form C-C and C-Het bonds, as it is atom economical and more efficient and greener than transition-metal catalyzed CDC reactions. Molecular iodine (I-2) is recognized as an inexpensive, environmentally benign, and easy-to-handle catalyst or reagent to pursue CDCs under mild reaction conditions, with good regioselectivities and broad substrate compatibility. This review presents the recent developments of I-2-catalyzed C-C, C-N, C-O, and C-S/C-Se bond-forming reactions for the synthesis of various important organic molecules by cross-dehydrogenative coupling.
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