4.6 Article

Rhodium(III)-Catalyzed Oxidative Annulation of Acrylic Acid with Alkynes: An Easy Approach to the Synthesis of α-Pyrones

Journal

CHEMISTRY-AN ASIAN JOURNAL
Volume 13, Issue 21, Pages 3281-3284

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201801190

Keywords

acrylic acid; C-H activation; oxidative annulation; rhodium; alpha-pyrone

Funding

  1. Natural Science Foundation of China [21772139, 21572149]
  2. Project of Scientific and Technologic Infrastructure of Suzhou [SZS201708]
  3. PAPD Project

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A highly efficient rhodium(III)-catalyzed direct oxidative annulation of acrylic acid with alkynes to form alpha-pyrones was developed. Various substituted acrylic acids were compatible in this transformation, affording the corresponding products in moderate to excellent yields under mild conditions.

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