Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 9, Issue 8, Pages 2295-2302Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201402256
Keywords
antitumor agents; cancer; coordination chemistry; reactive oxygen species; selenium
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Funding
- National Basic Research Program of China [2013CB834502]
- National Natural Science Foundation of China [21074066]
- Foundation for Innovative Research Groups of the National Natural Science Foundation of China [21121004]
- Chinese Ministry of Education [113006A]
- Tsinghua University Initiative Scientific Research Program [2012Z02131]
- Importation and Development of High-Caliber Talents Project of Beijing Municipal Institutions
- NSFC-DFG [TRR 61]
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We report the preparation of selenium-containing platinum-based anticancer drug EG-Se/Pt. EG-Se/Pt was obtained from the coordination of selenium-containing molecules (EGSe) with cisplatin (CDDP). The structure of EG-Se/Pt was characterized by H-1 and Se-77 NMR spectroscopy, XPS, ESI-MS, and MALDI-TOF. In aqueous solution, EG-Se/Pt self-assembles to form spherical aggregates. EG-Se/Pt shows enhanced stability against dilution and high salt concentration compared with EG-Se. EG-Se/Pt induces cell apoptosis via reactive oxygen species (ROS), which leads to high selectivity between cancer cells and normal cells in cytotoxicity assays. More importantly, EG-Se/Pt effectively inhibits tumor growth in vivo in tumor-bearing mice. It is anticipated that tuning the ROS level through the assembly of selenium-containing molecules can be a general method to realize anticancer selectivity.
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