Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 10, Issue 2, Pages 370-376Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201403133
Keywords
biodistribution; cancer; copper; nanoparticles; photothermal therapy; tumor ablation
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Funding
- National Natural Science Foundation of China [21101131]
- National Basic Research Foundation (973) of China [2014CB932004]
- Natural Science Foundation of Fujian Province [2012J01056]
- Fundamental Research Funds for the Central Universities [2010121015]
- open project grant from State Key Laboratory of Chemo/biosensing and Chemometrics [2013009]
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In this work, small sizes of hydrophobic copper sulfide nanoparticles (CuS NPs, similar to 3.8 nm in diameter) have been successfully prepared from the reaction of copper chloride with sodium diethyldithiocarbamate (SDEDTC) inside a heated oleylamine solution. These CuS NPs displayed strong absorption in the 700-1100 nm near-infrared (NIR) region. By coating CuS NPs with DSPE-PEG2000 on the surface, the as-synthesized CuS@DSPE-PEG NPs exhibited good water solubility, significant stability and biocompatibility, as well as excellent photothermal conversion effects upon exposure to an 808 nm laser. After intravenous administration to mice, the CuS@DSPE-PEG NPs were found to passively target to the tumor site, and tumor tissues could be ablated efficiency under laser irradiation. In addition, CuS@DSPE-PEG NPs do not show significant toxicity by histological and blood chemistry analysis, and can be effectively excreted via metabolism. Our results indicated that CuS@DSPE-PEG NPs can act as an ideal photothermal agent for cancer photothermal therapy.
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