4.8 Article

Ligand-Controlled Regiodivergent Copper-Catalyzed Alkylboration of Alkenes

Journal

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 44, Pages 12957-12961

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201506713

Keywords

copper; cross-coupling; difunctionalization; homogeneous catalysis; synthetic methods

Funding

  1. CAS [KJCX2-EW-J02]
  2. NSFC [21472181, 21325208, 21172209, 21272050]
  3. FANEDD [201424]
  4. SRFDP [20133402120034]
  5. FRFCU
  6. PCSIRT

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A novel copper-catalyzed regiodivergent alkylboration of alkenes with bis(pinacolato)diboron and alkyl halides has been developed. The regioselectivity of the alkylboration was controlled by subtle differences in the ligand structure. The reaction thus enables the practical, regiodivergent synthesis of two different alkyl boronic esters with complex structures from a single alkene.

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