Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 9, Issue 1, Pages 319-327Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201301105
Keywords
chitosan; drug delivery; mesoporous materials; nanoparticles; silica
Categories
Funding
- Natural Science Foundation of Guangxi [2013GXNSFBA019253]
- Science and Technology Research Project for Universities of Guangxi [2013ZD071]
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Herein, we present a straightforward synthesis of pH-responsive chitosan-capped mesoporous silica nanoparticles (MSNs). These MCM-41-type MSNs could be used as nanocapsules to accommodate guest molecules. Subsequently, (3-glycidyloxypropyl)trimethoxysilane was grafted onto the surface of the MSNs, which served as a bridge to link between MSNs and chitosan, which is ubiquitous in nature and commercially available. Owing to the pH-responsive and biocompatible features of chitosan, the loading and release of an anti-cancer drug, doxorubicin hydrochloride, were carried out invitro, in which the composite chitosan-capped MSNs (CS-MSNs) showed excellent environmental response. As the pH value of the media decreased, the degree of drug release correspondingly increased. Moreover, thanks to the perfect biocompatibility of chitosan, the CS-MSNs exhibited lower cytotoxicity than that of the naked MSNs in an MTT assay. In addition, the invitro kill potency against MCF-7 breast-cancer cells was enhanced over time, as well as with increasing concentration of the drug-loaded CS-MSNs. These results indicate that CS-MSNs are promising candidates for pH-responsive drug delivery in cancer therapy.
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