Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 7, Issue 4, Pages 830-837Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201100879
Keywords
cancer; lanthanides; magnetic resonance imaging; nanoparticles; photodynamic therapy
Categories
Funding
- NSFC [21101131, 21021061, 20925103, 20871100]
- Fok Ying Tung Education Foundation [121011]
- NSF of Fujian Province [2009J06005]
- Fundamental Research Funds for the Central Universities [2010121015]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars of State Education Ministry
- NFFTBS [J1030415]
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Lanthanide-doped upconversion nanoparticles (UCNPs) have attracted considerable attention for their application in biomedicine. Here, silica-coated NaGdF4:Yb,Er/NaGdF4 nanoparticles with a tetrasubstituted carboxy aluminum phthalocyanine (AlC4Pc) photosensitizer covalently incorporated inside the silica shells were prepared and applied in the photodynamic therapy (PDT) and magnetic resonance imaging (MRI) of cancer cells. These UCNP@SiO2(AlC4Pc) nanoparticles were uniform in size, stable against photosensitizer leaching, and highly efficient in photogenerating cytotoxic singlet oxygen under near-infrared (NIR) light. In vitro studies indicated that these nanoparticles could effectively kill cancer cells upon NIR irradiation. Moreover, the nanoparticles also demonstrated good MR contrast, both in aqueous solution and inside cells. This is the first time that NaGdF4:Yb,Er/NaGdF4 upconversion-nanocrystal-based multifunctional nanomaterials have been synthesized and applied in PDT. Our results show that these multifunctional nanoparticles are very promising for applications in versatile imaging diagnosis and as a therapy tool in biomedical engineering.
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