Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 7, Issue 5, Pages 1061-1068Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201101019
Keywords
arenes; cross-coupling; halides; lithiation; microreactors
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Funding
- Grants-in-Aid for Scientific Research [22750092, 21106002, 21106001, 12J05642] Funding Source: KAKEN
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The use of Pd catalysts that contained a carbene ligand, such as PEPPSI-SIPr, speeded up the Murahashi coupling of ArLi with ArBr, by enabling its integration with the Br/Li exchange of ArBr with BuLi in flow. Space integration realized the rapid cross-coupling of two different ArBr substrates. However, the cross-coupling reaction with vinyl halides could not be achieved under similar conditions. Pd(OAc)2 was an effective catalyst, and the space integration of the Br/Li exchange of ArBr with BuLi and the Murahashi coupling with vinyl halides was successfully achieved.
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