Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 7, Issue 2, Pages 400-405Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201100618
Keywords
amino acids; chirality; circular dichroism; combinatorial chemistry; lanthanides
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Funding
- Japan Society for the Promotion of Science [20245014]
- Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Agency (JST)
- Grants-in-Aid for Scientific Research [22350065] Funding Source: KAKEN
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A dynamic combinatorial library of lanthanide complexes was prepared to develop induced-circular-dichroism (CD) chirality probes. It totaled 168 combinations of coordinative N-aromatic chromophores, trivalent lanthanide centers, and guest amino acids. Eu3+ and Tb3+ complexes prepared with quinolinecarboxylic acid were particularly effective as induced-CD chirality probes for selective alanine detection, whereas a Yb3+ complex with terpyridine exhibited glutamine selectivity. The former two complexes highly preferred alanine to the corresponding amine, ester, amino alcohol, and carboxylic acid derivatives. As such, the present combinatorial screening of a dynamic lanthanide complex library has led to a new series of induced-CD chirality probes for specific amino acids.
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