Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 6, Issue 6, Pages 1381-1389Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201000905
Keywords
click chemistry; doxorubicin; drug delivery; enzymes; intracellular imaging
Categories
Funding
- Nanyang Technological University, Singapore [4RG64/10, 07/1/22/19/534]
- National Institute of Health (NIH), USA [NIH1R41A137960, NCIP50A119367]
Ask authors/readers for more resources
Enzyme-responsive, hybrid, magnetic silica nanoparticles have been employed for multifunctional applications in selective drug delivery and intracellular tumor imaging. In this study, doxorubicin (Dox)-conjugated, enzyme-cleavable peptide precursors were covalently tethered onto the surface of uniform silica-coated magnetic nanoparticles through click chemistry. This enzyme-responsive nanoparticle conjugate demonstrated highly efficient Dox release upon specific enzyme interactions in vitro. It also exhibits multiple functions in selective tumor intracellular drug delivery and imaging in the tumor cells with high cathepsin B expression, whereas it exhibited lower cytotoxicity towards other cells without enzyme expression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available