Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 5, Issue 4, Pages 704-754Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.200900634
Keywords
anti-Alzheimer's drugs; antitumor agents; bryostatin; protein kinase c; total synthesis
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Funding
- Medical Research Council [G0802079] Funding Source: Medline
- MRC [G0802079] Funding Source: UKRI
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In this Focus Review, we give an overview of various bryostatin total syntheses. We also discuss the synthesis of various bryostatin analogues and their biological activity. Work reviewed includes that of Masamune. Evans, Nishiyama and Yamamura. Hale and Manaviazar, Trost, Wender, Keck, Burke, Thomas, and Krische. Our coverage is primarily for the period 2001-2009 since detailed reviews already exist on bryostatin total synthesis work and biology up to this time.
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