4.6 Review

New Approaches to the Total Synthesis of the Bryostatin Antitumor Macrolides

Journal

CHEMISTRY-AN ASIAN JOURNAL
Volume 5, Issue 4, Pages 704-754

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.200900634

Keywords

anti-Alzheimer's drugs; antitumor agents; bryostatin; protein kinase c; total synthesis

Funding

  1. Medical Research Council [G0802079] Funding Source: Medline
  2. MRC [G0802079] Funding Source: UKRI

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In this Focus Review, we give an overview of various bryostatin total syntheses. We also discuss the synthesis of various bryostatin analogues and their biological activity. Work reviewed includes that of Masamune. Evans, Nishiyama and Yamamura. Hale and Manaviazar, Trost, Wender, Keck, Burke, Thomas, and Krische. Our coverage is primarily for the period 2001-2009 since detailed reviews already exist on bryostatin total synthesis work and biology up to this time.

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