Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 4, Issue 12, Pages 1809-1816Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.200900276
Keywords
core-shell structures; homogeneous nucleation; imaging agents; nanostructures; microemulsions
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Funding
- National Natural Science Foundation of China Research [50672115, 50823007]
- Shanghai Rising-Star Program [07A14061]
- Shanghai Nano-special Project [0852NM03900]
- CASKJCX [KJCX2.YNV.M02, KJCX2-YW-210]
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Oleic acid stabilized superparamagnetic iron oxide nanoparticles (SPION) were selected as the cores for fabrication of sub-50-nm monodisperse single-loaded SPION@SiO2 core-shell nanostructures. Parameters that influence the formation of SPION@SiO2 in the water-in-oil reverse microemulsion system have been systematically investigated. The sufficiently high concentration of well-dispersed SPION, together with an appropriately low injection rate of tetraethoxysilane, were found to be the keys to efficiently prevent the homogeneous nucleation of silica and obtain a high-quality single-loaded core-shell nanocomposite. A more detailed mechanism for incorporating oleic acid capped inorganic functional nanoparticles into silica is proposed on the basis of previous reports and our new experimental results. Finally, the as-synthesized SPION@SiO2 nanospheres are exploited as an MRI-enhanced contrast agent, and their contrast effect in Solution is tested by using a clinical MRI instrument.
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