Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 3, Issue 11, Pages 1890-1899Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.200800149
Keywords
anticancer agents; arene ligands; organometallics; osmium; ruthenium
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The field of medicinal inorganic chemistry is rapidly advancing. In particular organometallic complexes have much potential as therapeutic and diagnostic agents. The carbon-bound and other ligands allow the thermodynamic and kinetic reactivity of the metal ion to be controlled and also provide a scaffold for functionalization. The establishment of structure-activity relationships and elucidation of the speciation of complexes under conditions relevant to drug testing and formulation are crucial for the further development of promising medicinal applications of organometallic complexes. Specific examples involving the design of ruthenium and osmium arene complexes as anticancer agents are discussed.
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