Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 20, Issue 47, Pages 15320-15324Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201404965
Keywords
crystal engineering; drug delivery; LMWGS; supramolecular gels; supramolecular synthons
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Funding
- DBT, New Delhi (CEIB) [BT/01/CEIB/V/13]
- CSIR, New Delhi (CSIR) [09/080(0802)/2012-EMR-I]
- DBT
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A simple strategy for designing salt-based supramolecular gelators comprised of various nonsteroidal anti-inflammatory drugs (NSAIDs) and amantadine (AMN) (an antiviral drug) has been demonstrated using a supramolecular synthon approach. Single-crystal and powder X-ray diffraction established the existence of the well-studied gel-forming 1D supramolecular synthon, namely, primary ammonium monocarboxylate (PAM) synthon in all the salts. Remarkably five out of six salts were found to be capable of gelling methyl salicylate (MS)-an important ingredient in commercially available topical gels; one such selected biocompatible salt displayed an anti-inflammatory response in prostaglandin E-2 (PGE(2)) assay, thereby indicating their plausible biomedical applications.
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