Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 21, Issue 2, Pages 549-553Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201405276
Keywords
amines; asymmetric catalysis; hydrogenation; ruthenium; transfer hydrogenation
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Funding
- Junta de Andalucia [2009/FQM-4832]
- MICINN [CTQ2011-26481]
- FICYT (Principado de Asturias)
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The asymmetric reduction of N-aryl imines derived from acetophenones by using Ru complexes bearing both a pybox (2,6-bis(oxazoline) pyridine) and a monodentate phosphite ligand has been described. The catalysts show good activity with a diverse range of substrates, and deliver the amine products in very high levels of enantioselectivity (up to 99%) under both hydrogenation and transfer hydrogenation conditions in isopropanol. From deuteration studies, a very different labeling is observed under hydrogenation and transfer hydrogenation conditions, which demonstrates the different nature of the hydrogen source in both reactions.
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