Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 20, Issue 50, Pages 16488-16491Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201404625
Keywords
cell imaging; glutathione; manganese dioxide; nanoparticles; nanotechnology
Categories
Funding
- 973 Program [2013CB933800]
- National Natural Science Foundation of China [21227005, 21390411, 91313302, 21035003, 21422505, 21375081]
Ask authors/readers for more resources
Persistent luminescence nanoparticles (PLNPs) hold great promise for the detection and imaging of biomolecules. Herein, we have demonstrated a novel nanoprobe, based on the manganese dioxide (MnO2)-modified PLNPs, that can detect and image glutathione in living cells and in vivo. The persistent luminescence of the PLNPs can be efficiently quenched by the MnO2 nanosheets. In the presence of glutathione (GSH), MnO2 was reduced to Mn2+ and the luminescence of PLNPs can be restored. The persistent luminescence property can allow detection and imaging without external excitation and avoid the background noise originating from the in situ excitation. This strategy can offer a promising platform for detection and imaging of reactive species in living cells or in vivo.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available