Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 20, Issue 35, Pages 10921-10925Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201404296
Keywords
cytotoxicity; mesoporous silica nanoparticles; photodynamic therapy; Rose Bengal; singlet oxygen
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Funding
- Masterlight project (Bando di Ateneo CSP)
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
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Organically modified mesoporous silica nanoparticles (MSNs) containing rose bengal (RB), a xanthene dye, were successfully synthesized. RB-modified MSNs have shown a relevant photostability and a high efficiency in the photoproduction and delivery of singlet oxygen (O-1(2)), which is particularly promising for photodynamic therapy (PDT) applications. In vitro tests have evidenced that RB-MSNs are able to reduce cell proliferation in one of the most aggressive skin cancer types (SK-MEL-28) after green-light irradiation.
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