Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 20, Issue 20, Pages 6184-6191Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201400079
Keywords
amyloid beta-peptides; amyloid fibrils; curcumin; fibril dissolution; gold nanoparticles; neurochemistry
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Funding
- Department of Biotechnology (DBT)
- Department of Science and Technology (DST) of the Government of India
- Council for Scientific and Industrial Research (CSIR), India
- DST
- Indian Association for the Cultivation of Science
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Inhibition of amyloid fibrillation and clearance of amyloid fibrils/plaques are essential for the prevention and treatment of various neurodegenerative disorders involving protein aggregation. Herein, we report curcumin-functionalized gold nanoparticles (Au-curcumin) of hydrodynamic diameter 10-25nm, which serve to inhibit amyloid fibrillation and disintegrate/dissolve amyloid fibrils. In nanoparticle form, curcumin is water-soluble and can efficiently interact with amyloid protein/peptide, offering enhanced performance in inhibiting amyloid fibrillation and dissolving amyloid fibrils. Our results imply that nanoparticle-based artificial molecular chaperones may offer a promising therapeutic approach to combat neurodegenerative disease.
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