Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 20, Issue 11, Pages 2998-3004Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201304864
Keywords
acetylcholine; drug delivery; macrocyclic chemistry; mesoporous materials; silica nanoparticles
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Funding
- National Natural Science Foundation of China [21272093]
- Specialized Research Fund for the Doctoral Program of Higher Education of China [20120061120117]
- Innovation Program of the State Key Laboratory of Supramolecular Structure and Materials
- Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Central China Normal University [201301A01]
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Acetylcholine (ACh), a neurotransmitter located in cholinergic synapses, can trigger cargo release from mesoporous silica nanoparticles equipped with calixarene- or pillarene-based nanovalves by removing macrocycles from the stalk components. The amount and speed of cargo release can be controlled by varying the concentration of ACh in solution or changing the type of gating macrocycle. Although this proof-of-concept study is far from a real-life application, it provides a possible route to treat diseases related to the central nervous system.
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