Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 20, Issue 14, Pages 3894-3897Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201303622
Keywords
human serum albumin; hydrolysis; metalloproteases; polyoxometalates
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Funding
- FWO Flanders (Belgium)
- FWO Flanders
- KU Leuven Research Fund [START1/09/028]
- Concerted Research Actions of the Regional Government of Flanders [G.O.A./2007/15]
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Complexes comprising the Lewis acidic Zr-IV metal and protein binding polyoxotungstate ligands of Lindqvist-, Keggin- and Wells-Dawson-type were found to region selectively hydrolyze human serum albumin at four distinct positions. Higher reactivities were found for structures with higher polyoxometalate charges and the cleavage positions were found in protein regions of mixed charge. Both findings suggest an electrostatic nature of the observed reactivity.
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