4.6 Article

Lipase-Supported Metal-Organic Framework Bioreactor Catalyzes Warfarin Synthesis

Journal

CHEMISTRY-A EUROPEAN JOURNAL
Volume 21, Issue 1, Pages 115-119

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201405252

Keywords

green chemistry; lipase; metal-organic frameworks; physical adsorption; warfarin

Funding

  1. Ministry of Science and Technology of Taiwan [MOST 103-2632M-033-001-MY3, NSC-101-2113M-033-002-MY3]
  2. Chung Yuan Christian University

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A green and sustainable strategy synthesizes clinical medicine warfarin anticoagulant by using lipase-supported metal-organic framework (MOF) bioreactors (see scheme). These findings may be beneficial for future studies in the industrial production of chemical, pharmaceutical, and agrochemical precursors.

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