Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 20, Issue 37, Pages 11913-11920Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201402820
Keywords
antioxidants; curcumin; electrocatalysis; magnetic nanoparticles; MRI contrast agents
Categories
Funding
- Italian Institutional Ministry [cod. 60A06-7411, 60A06-8055]
- Operational Program Research and Development for Innovations-European Regional Development Fund [CZ.1.05/2.1.00/03.0058]
- Operational Program Education for Competitiveness-European Social Fund of the Ministry of Education, Youth and Sports of the Czech Republic [CZ.1.07/2.3.00/20.0155]
- Grant Agency of the Academy of Sciences of the Czech Republic [KAN115600801, KAN200380801]
- Internal IGA grant of the Palacky University in Olomouc [PrF_2013_014]
- Internal Student Grants (IGA) of Palacky University in Olomouc, Czech Republic [PrF_2013_014, PrF_2013_028]
Ask authors/readers for more resources
Curcumin possesses wide-ranging anti-inflammatory and anti-cancer properties and its biological activity can be linked to its potent antioxidant capacity. Superparamagnetic maghemite (gamma-Fe2O3), called surface-active maghemite nanoparticles (SAMNs) were surface-modified with curcumin molecules, due to the presence of under-coordinated Fe-III atoms on the nanoparticle surface. The so-obtained curcumin-modified SAMNs (SAMN@curcumin) had a mean size of 13 +/- 4 nm. SAMN@curcumin was characterized by transmission and scanning electron microscopy, UV/Vis, FTIR, and Mossbauer spectroscopy, X-ray powder diffraction, bulk susceptibility (SQUID), and relaxometry measurements (MRI imaging). The high negative contrast proclivity of SAMN@curcumin to act as potential contrast agent in MRI screenings was also tested. Moreover, the redox properties of bound curcumin were probed by electrochemistry. SAMN@curcumin was studied in the presence of different electroactive molecules, namely hydroquinone, NADH and ferrocyanide, to assess its redox behavior. Finally, SAMN@curcumin was electrochemically probed in the presence of hydrogen peroxide, demonstrating the stability and reactivity of bound curcumin.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available