Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 20, Issue 23, Pages 6861-6865Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201402573
Keywords
cancer; cisplatin; click chemistry; nanoparticles; prodrugs
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Funding
- Office of the Vice President for Research, University of Georgia (UGA)
- Department of Defense Prostate Cancer Idea award [W81XWH-12-1-0406]
- National Institutes of Health [R01A157766]
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The ability to rationally design and construct a platform technology to develop new platinum(IV) [PtIV] prodrugs with functionalities for installation of targeting moieties, delivery systems, fluorescent reporters from a single precursor with the ability to release biologically active cisplatin by using well-defined chemistry is critical for discovering new platinum-based therapeutics. With limited numbers of possibilities considering the sensitivity of PtIV centers, we used a strain-promoted azide-alkyne cycloaddition approach to provide a platform, in which new functionalities can easily be installed on cisplatin prodrugs from a single PtIV precursor. The ability of this platform to be incorporated in nanodelivery vehicle and conjugation to fluorescent reporters were also investigated.
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