Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 20, Issue 33, Pages 10514-10518Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201402244
Keywords
ball-milling; doxorubicin; drug delivery; metal-organic frameworks; nanocarriers
Categories
Funding
- CSIR's XIIth Five Year Plan Project [CSS0102, CSS0122]
- DFG
- DBT project
- NAIP project
- National Fund (ICAR) project
- ISI plan project
- BRNS
- UR
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A Gd-III-based porous metal-organic framework (MOF), Gd-pDBI, has been synthesized using fluorescent linker pDBI (pDBI=(1,4-bis(5-carboxy-1H-benzimidazole-2-yl)benzene)), resulting in a three-dimensional interpenetrated structure with a one-dimensional open channel (1.9x1.2nm) filled with hydrogen-bonded water assemblies. Gd-pDBI exhibits high thermal stability, porosity, excellent water stability, along with organic-solvent and mild acid and base stability with retention of crystallinity. Gd-pDBI was transformed to the nanoscale regime (ca. 140nm) by mechanical grinding to yield MG-Gd-pDBI with excellent water dispersibility (>90min), maintaining its porosity and crystallinity. In vitro and in vivo studies on MG-Gd-pDBI revealed its low blood toxicity and highest drug loading (12wt%) of anticancer drug doxorubicin in MOFs reported to date with pH-responsive cancer-cell-specific drug release.
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