Silver-Catalyzed Cross-Coupling of Propargylic Alcohols with Isocyanides: An Atom-Economical Synthesis of 2,3-Allenamides

Cross-coupling reactions between propargylic alcohols and isocyanides, by means of silver catalysis, have been described. This new reaction is both atom and step efficient and is applicable to a broad scope of substrates, allowing the synthesis of a range of synthetically valuable 2,3-allenamides in moderate to excellent yields.