Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 21, Issue 8, Pages 3156-3166Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201405253
Keywords
dynamic nuclear polarization; hyperpolarization; medicinal chemistry; molecular imaging; spin exchange optical pumping
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Funding
- NIH [1R21EB018014]
- National Science Foundation [CHE-1416268]
- CDMRP Breast Cancer Program Era of Hope Award [W81XWH-12-1-0159/BC112431]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1416268, 1416432] Funding Source: National Science Foundation
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Recent developments in NMR hyperpolarization have enabled a wide array of new in vivo molecular imaging modalities, ranging from functional imaging of the lungs to metabolic imaging of cancer. This Concept article explores selected advances in methods for the preparation and use of hyperpolarized contrast agents, many of which are already at or near the phase of their clinical validation in patients.
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