Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 20, Issue 21, Pages 6241-6245Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201400001
Keywords
glutathione; photodynamic therapy; photosensitizers; phthalocyanines; singlet oxygen
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Funding
- Research Grant Council of the Hong Kong Special Administrative Region [402211]
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A zinc(II) phthalocyanine substituted with a 2,4-dinitrobenzenesulfonate group has been prepared. Its fluorescence emission and reactive oxygen species generation can be greatly enhanced by glutathione in phosphate-buffered saline and inside MCF-7 cells. This compound thus functions as a highly efficient molecular-based activatable photosensitizer.
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