Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 20, Issue 47, Pages 15330-15333Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201404084
Keywords
atomic force microscopy; chemical modification; nanostructures; RNA; transcription
Categories
Funding
- Core Research for Evolutional Science and Technology (CREST) of JST
- JSPS KAKENHI [24310097, 24104002, 25253004, 26620133]
- Mitsubishi Foundation
- Asahi Glass Foundation
- Grants-in-Aid for Scientific Research [25253004, 24104002, 26620133] Funding Source: KAKEN
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In nucleic acid nanotechnology, designed RNA molecules are widely explored because of their usability originating from RNA's structural and functional diversity. Herein, a method to design and prepare RNA nanostructures by employing DNA origami strategy was developed. A single-stranded RNA scaffold and staple RNA strands were used for the formation of RNA nanostructures. After the annealing of the mixtures, 7-helix bundled RNA tile and 6-helix bundled RNA tube structures were observed as predesigned shapes. These nanostructures were easily functionalized by introducing chemical modification to the RNA scaffolds. The DNA origami method is extended and utilized to construct RNA nanostructures.
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