Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 20, Issue 46, Pages 15053-15060Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201403986
Keywords
biological evaluation; enyne cyclization; structure elucidation; tandem reaction; total synthesis
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Funding
- NNSFC [21202144, J1210042]
- New Teacher's Fund for Doctor Stations, Ministry of Education [20120101120087]
- Zhejiang University
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In this study, a concise and stereoselective approach for the divergent total synthesis of (-)-indoxamycins A-F is described. The key steps of the strategy include an Ireland-Claisen rearrangement, an enantioselective 1,6-enyne reductive cyclization, and a tandem 1,2-addition/oxa-Michael/methylenation reaction. The relative and absolute configuration of these natural products has been unambiguously elucidated, and their cytotoxic activities against HT-29 and A-549 tumor cell lines are also reported.
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