Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 21, Issue 1, Pages 101-105Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201404520
Keywords
anti-cancer prodrugs; high drug loading; nanomedicines; self-assembly
Categories
Funding
- National Science Foundation [CHE-1412295]
- Boston University Flow Cytometry Core Facility
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1057884, 1412295] Funding Source: National Science Foundation
Ask authors/readers for more resources
20-(S)-Camptothecin (CPT)-conjugated dipeptides are reported that preassemble into nanotubes with diameters ranging from 80-120 nm. These nanoassemblies maintain a high (similar to 47%) drug loading and exhibit greater drug stability (i.e., resistance to lactone hydrolysis), and consequently greater efficacy against several human cancer cells (HT-29, A549, H460, and H23) in vitro compared with the clinically used prodrug irinotecan. A key and defining feature of this system is the use of the CPT-conjugated dipeptide as both the drug and precursor to the nanostructured carrier, which simplifies the overall fabrication process.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available