Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 20, Issue 48, Pages 15991-15997Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201403958
Keywords
antibiotics; natural products; NMR spectroscopy; polyketides; structure elucidation
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Funding
- National Science Council of Taiwan [NSC 101-2113M-007-018-MY3, NSC 101-2811M-007-033, NSC 102-2811M-007-003]
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The gulmirecins constitute a new class of glycosylated macrolides that were isolated from the predatory bacterium Pyxidicoccus fallax HKI 727. Their structures were solved by a combination of NMR spectroscopic experiments and chemical derivatization. Analysis of the annotated gulmirecin gene cluster complemented the configurational assignment and provided insights into the stereochemical course of the biosynthetic assembly. The gulmirecins exhibit strong activity against staphylococci, including methicillin-resistant Staphylococcus aureus, but no cytotoxic effects on human cells.
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