Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 20, Issue 11, Pages 3135-3141Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201304314
Keywords
carbonylative coupling; CH bond functionalization; heterocycles; multicomponent reactions; ruthenium
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Funding
- state of Mecklenburg-Vorpommern
- Bundesministerium fur Bildung und Forschung (BMBF)
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A ruthenium-catalyzed carbonylative CH bond arylation process for the three-component synthesis of complex aryl-(hetero)aryl ketones in an aqueous solution has been developed. By exploiting the ortho-activating effect of nitrogen-containing directing groups, a regioselective, successive twofold C(sp(2))C(sp(2)) bond formation has been achieved. This straightforward catalytic process provides access to versatile products prevalent in multiple bioactive compounds and supplies a valuable functional group for subsequent transformations.
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