Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 20, Issue 9, Pages 2463-2468Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201304701
Keywords
alkynes; benzynes; CN activation; carbodiimides; multicomponent reactions
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Funding
- Natural Science Foundation of China
- 973 Program [2011CB808600]
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A novel pattern of the cleavage and reorganization of CN bond in the multicomponent reaction (MCR) of terminal alkynes or haloalkynes, carbodiimides, and benzynes is achieved for the first time to construct efficiently 2-aminoaryl alkynyl imines. The selective formation and ring-opening of the azetine intermediate with the high ring strain is essential for this reaction. Further transformation of 2-aminoaryl alkynyl imines via the Cu-catalyzed cycloisomerization is explored to provide steroselectively the bi-, tri-, and tetracyclic fused pyrrolines.
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