Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 20, Issue 33, Pages 10292-10297Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201402828
Keywords
fluorescence lifetime; indocyanine green; nanocapsules; thermometers; vesicles
Categories
Funding
- National Cancer Institute of the NIH [R21A149814]
- National Heart Lung and Blood Institute as a Program of Excellence in Nanotechnology [HHSN268201000046C]
- National Institute of Arthritis and Musculoskeletal and Skin Diseases [R21AR060408]
- National Science Foundation [CHE-1316680]
- Saint Louis University Presidential Research Fund
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1522525] Funding Source: National Science Foundation
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We have developed a novel design of optical nanothermometers that can measure the surrounding temperature in the range of 20-85 degrees C. The nanothermometers comprise two organic fluorophores encapsulated in a crosslinked polymethacrylate nanoshell. The role of the nanocapsule shell around the fluorophores is to form a well-defined and stable microenvironment to prevent other factors besides temperature from affecting the dyes' fluorescence. The two fluorophores feature different temperature-dependent emission profiles; a fluorophore with relatively insensitive fluorescence (rhodamine 640) serves as a reference whereas a sensitive fluorophore (indocyanine green) serves as a sensor. The sensitivity of the nanothermometers depends on the type of nanocapsule-forming lipid and is affected by the phase transition temperature. Both the fluorescence intensity and the fluorescence lifetime can be utilized to measure the temperature.
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