Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 21, Issue 3, Pages 1179-1183Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201405470
Keywords
anticancer agents; EPR spectroscopy; photodynamic therapy; porphyrinoids
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Funding
- Forschungskredit
- University of Zurich
- Thai Government
- Swiss National Science Foundation [PP00P2_133568]
- Stiftung fur Wissenschaftliche Forschung of the University of Zurich
- UBS Promedica Stiftung
- Swiss National Science Foundation (SNF) [PP00P2_133568] Funding Source: Swiss National Science Foundation (SNF)
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Novel photoactive (metallo)porphyrins were synthesised and characterised. When irradiated with light at a wavelength greater than 600nm, these porphyrins act as photosensitisers and show high cytotoxicity towards two different human cancer cell lines with IC50 values down to 0.4M. A paramagnetic copper(II) porphyrin is the first photosensitiser to display excellent phototoxicity, explained by the electron paramagnetic resonance (EPR) spin trapping of hydroxy radicals and experimentally confirmed by the discovery of elevated levels of reactive oxygen species (ROS) inside A2780 cells after irradiation with red light. This finding indicates that paramagnetic compounds should be considered for photodynamic therapy (PDT). Furthermore, an additive effect of cisplatin and a zinc porphyrin, both at subtherapeutic concentrations of 0.22m, was observed.
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