Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 20, Issue 28, Pages 8604-8614Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201403103
Keywords
cyclometalation; gold; luminescence; N-heterocyclic carbenes; water chemistry
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Funding
- University Grants Committee of the HKSAR, China [AoE/P-03/08]
- Hong Kong Research Grants Council [HKU-700812]
- National Key Basic Research Program of China [2013CB834802]
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A new class of cyclometalated Au-III complexes containing various bidentate C-deprotonated (CN)-N-boolean AND and cis-chelating bis(N-heterocyclic carbene) (bis-NHC) ligands has been synthesized and characterized. These are the first examples of Au-III complexes supported by cis-chelating bis-NHC ligands. [Au((CN)-N-boolean AND)(bis-NHC)] complexes display emission in solutions under degassed condition at room temperature with emission maxima (lambda(max)) at 498-633 nm and emission quantum yields of up to 10.1 %. The emissions are assigned to triplet intraligand (IL) pi ->pi* transitions of (CN)-N-boolean AND ligands. The Au-III complex containing a (CN)-N-boolean AND (C-deprotonated naphthalene-substituted quinoline) ligand with extended pi-conjugation exhibits prompt fluorescence and phosphorescence of comparable intensity with lambda(max) at 454 and 611 nm respectively. With sulfonate-functionalized bis-NHC ligand, four water-soluble luminescent Au-III complexes, including those displaying both fluorescence and phosphorescence, were prepared. They show similar photophysical properties in water when compared with their counterparts in acetonitrile. The long phosphorescence lifetime of the water-soluble AuIII complex with C-deprotonated naphthalene-substituted quinoline ligand renders it to function as ratiometric sensor for oxygen. Inhibitory activity of one of these water-soluble Au-III complexes towards deubiquitinase (DUB) UCHL3 has been investigated; this complex also displayed a significant inhibitory activity with IC50 value of 0.15 mu m.
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