4.6 Article

A Two-Armed Lanthanoid-Chelating Paramagnetic NMR Probe Linked to Proteins via Thioether Linkages

Journal

CHEMISTRY-A EUROPEAN JOURNAL
Volume 20, Issue 21, Pages 6256-6258

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201400257

Keywords

lanthanides; paramagnetic NMR; protein modification; protein structures; pseudocontact shift

Funding

  1. Netherlands Organisation for Scientific Research [700.58.441, 700.10.407]

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Paramagnetic NMR probes provide valuable long-range structural information on proteins and protein complexes. A new, stable, two-armed lanthanoid probe is reported that can be attached to a protein site-specifically via chemically inert thioether linkages.

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