Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 19, Issue 40, Pages 13484-13491Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201301461
Keywords
core-shell microspheres; liquid chromatography; metal-organic frameworks; stationary phases; zeolites
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Funding
- National Natural Science Foundation of China [20935001, 21077057]
- Fundamental Research Funds for the Central Universities
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The unique features of high porosity, shape selectivity, and multiple active sites make metal-organic frameworks (MOFs) promising as novel stationary phases for high-performance liquid chromatography (HPLC). However, the wide particle size distribution and irregular shape of conventional MOFs lead to lower column efficiency of such MOF-packed columns. Herein, the fabrication of monodisperse MOF@SiO2 core-shell microspheres as the stationary phase for HPLC to overcome the above-mentioned problems is reported. Zeolitic imidazolate framework8 (ZIF-8) was used as an example of MOFs due to its permanent porosity, uniform pore size, and exceptional chemical stability. Unique carboxyl-modified silica spheres were used as the support to grow the ZIF-8 shell. The fabricated monodisperse ZIF-8@SiO2 packed columns (5cm long x 4.6mm i.d.) show high column efficiency (23000platesm(-1) for bisphenolA) for the HPLC separation of endocrine-disrupting chemicals (bisphenolA, -estradiol, and p-(tert-octyl)phenol) and pesticides (thiamethoxam, hexaflumuron, chlorantraniliprole, and pymetrozine) within 7min with good relative standard deviations for 11replicate separations of the analytes (0.01-0.39, 0.65-1.7, 0.70-1.3, and 0.17-0.91% for retention time, peak area, peak height, and half peak width, respectively). The ZIF-8@SiO2 microspheres combine the advantages of the good column packing properties of the uniform monodisperse silica microspheres and the separation ability of the ZIF-8 crystals.
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