Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 20, Issue 1, Pages 93-97Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201303641
Keywords
beta-ketoesters; asymmetric catalysis; copper; pincer ligands; trifluoromethylthiolation
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Funding
- University of Heidelberg
- State of Baden-Wurttemberg
- BASF SE
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The enantioselective trifluoromethylthiolation of -ketoesters using chiral copper-boxmi complexes as catalysts is reported. A number of -SCF3-substituted -ketoesters have been obtained with up to >99% enantiomeric excess (ee), and the trifluoromethylthiolated products were then transformed diastereoselectively to -SCF3--hydroxyesters with two adjacent quaternary stereocenters.
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