Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 20, Issue 1, Pages 34-41Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201302426
Keywords
bioconjugation; biomolecular recognition; chemoselectivity; multivalency; oxime
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Funding
- Universite Joseph Fourier (UJF)
- Centre National de la Recherche Scientifique (CNRS)
- Agence Nationale de la Recherche LabEx [ANR-11-LABX-0003-01]
- Communaute d'agglomeration Grenoble-Alpes Metropole (Nanobio Program)
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There is a growing need for biocompatible click reactions in order to prepare multifunctional conjugates, which are valuable molecules for innovative biomedical applications. In this context, we review the recent advances in the implementation of oxime ligation for the synthesis of multivalent or multicomponent systems. The value of these products is emphasized by their use in cell targeting, imaging, synthetic vaccines, and surface modifications.
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