The Redox-Neutral Approach to C-H Functionalization

The direct functionalization of CH bonds is an attractive strategy in organic synthesis. Although several advances have been made in this area, the selective activation of inert sp(3) CH bonds remains a daunting challenge. Recently, a new type of sp(3) CH activation mode through internal hydride transfer has demonstrated the potential to activate remote sp(3) CH linkages in an atom-economic manner. This Minireview attempts to classify recent advances in this area including the transition to non-activated sp(3) CH bonds and asymmetric hydride transfers.