Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 20, Issue 4, Pages 1010-1016Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201303757
Keywords
cell imaging; cyclization; fluorescence; fluorescent probes; hydrogen sulfide
Categories
Funding
- American Chemical Society-Teva USA Scholar Grant
- NIH [R01M088226]
Ask authors/readers for more resources
The design, synthesis, properties, and cell imaging applications of a series of 2-pyridyl disulfide based fluorescent probes (WSP1, WSP2, WSP3, WSP4 and WSP5) for hydrogen sulfide detection are reported. The strategy is based on the dual-nucleophilicity of hydrogen sulfide. A hydrogen sulfide mediated tandem nucleophilic substitution-cyclization reaction is used to release the fluorophores and turn on the fluorescence. The probes showed high sensitivity and selectivity for hydrogen sulfide over other reactive sulfur species, including cysteine and glutathione.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available