The Relationship between DNA Sequences and Oligonucleotide-Templated Silver Nanoclusters and Their Fluorescence Properties

A novel approach was developed to study the relationship between DNA sequences and DNA-templated silver nanoclusters (DNA-Ag NCs) in detail by using an ordinary DNA strand as an example. Three kinds of Ag NCs are formed by using the DNA strand as a scaffold. By dividing the DNA template into several parts according to their different affinities to Ag+, it was found that the fluorescence properties of DNA-Ag NCs are related to not only the sequences but also to the position of different parts in the template, which provides a more efficient approach to obtain DNA-Ag NCs with required photoluminescence properties and may ultimately contribute to the targeted synthesis of DNA-Ag NCs.