4.6 Article

Cyclization-Induced Turn-On Fluorescence System Applicable to Dicarboxylate Sensing

Journal

CHEMISTRY-A EUROPEAN JOURNAL
Volume 20, Issue 2, Pages 381-384

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201304031

Keywords

cooperativity; dicarboxylic acid; fluorescence; molecular recognition; nonlinear response

Funding

  1. [25810051]
  2. Grants-in-Aid for Scientific Research [25810051] Funding Source: KAKEN

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A novel tetraphenylethene-based fluorescence (FL) chemosensor exhibits nonlinear turn-on FL switching though cooperative binding of l-tartarate, where its convergent binding to form cyclic substructures is responsible for the FL increase. This binding scheme achieves selective detection of dicarboxylates over monocarboxylates, thus is potentially applicable to the preliminary screening for metabolic disorders.

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