Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 19, Issue 49, Pages 16646-16650Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201302647
Keywords
cellular imaging; fluorescence; nanoparticles; self-assembly; supramolecular chemistry
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Funding
- Ministry of Education, Culture and Science [024.001.035]
- ERC [310275 - BioNLight]
- CTMM [03O-201 Mammoth]
- Netherlands Foundation for Scientific Research (NWO)
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Fluorescent, cell-permeable, organic nanoparticles based on self-assembled -conjugated oligomers with high absorption cross-sections and high quantum yields have been developed. The nanoparticles are generated with a tuneable density of amino groups for charge-mediated cellular uptake by a straightforward self-assembly protocol, which allows for control over size and toxicity. The results show that a single amino group per ten oligomers is sufficient to achieve cellular uptake. The non-toxic nanoparticles are suitable for both one- and two-photon cellular imaging and flow cytometry, and undergo very efficient cellular uptake.
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