Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 19, Issue 43, Pages 14420-14424Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201303025
Keywords
copper; cyclization; enynes; regioselectivity; trifluoromethylation
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Funding
- National Science Foundation [NSF21072081]
- National Basic Research Program of China (973 Program) [2010CB8-33203]
- 111 Project
- Program for Changjiang Scholars and innovative Research Team in University [IRT1138]
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Regioselective trifluoromethylation-cyclization: A method for copper-catalyzed trifluoromethylation-cyclization of simple enynes using the C-C triple bond as a nucleophile is reported for the first time (see scheme). The reaction proceeds efficiently in a highly regioselective manner to give various 5- or 6-exo-dig carbocycles and heterocycles in moderate to high yields.
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