Electron Capture by the Thiyl Radical and Disulfide Bond: Ligand Effects on the Reduction Potential

The effect of non-polar and polar ligands and of monovalent cations on the one-electron reduction potential of the thiyl radical and the disulfide bond was evaluated. The reduction potentials E degrees for the CH3S.nL/CH3SnL and CH3SSCH3L/CH3SSCH3.L redox couples were calculated at the B3LYP, M06-2X and MP2 levels of theory, with n=1, 2 and L=CH4, C2H4, H2O, CH3OH, NH3, CH3COOH, CH3CONH2, NH4+, Na+, K+ and Li+. Non-polar ligands decrease the E degrees value of the thiyl radical and disulfide bond, while neutral polar ligands favour electron uptake. Charged polar ligands and cations favour electron capture by the thiyl radical while disfavouring electron uptake by the disulfide bond. Thus, the same type of ligand can have a different effect on E degrees depending on the redox couple. Therefore, properties of an isolated ligand cannot uniquely determine E degrees. The ligand effects on E degrees are discussed in terms of the vertical electron affinity and reorganization energy, as well as molecular orbital theory. For a given redox couple, the ligand type influences the nature of the anion formed upon electron capture and the corresponding reorganization process towards the reduced geometry.