Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 19, Issue 14, Pages 4548-4555Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201203922
Keywords
bioluminescence; cancer; photodynamic therapy; photon donor; photosensitizer
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Funding
- National Basic Research Program of China (973 Program) [2009CB930101]
- National Nature Science Foundation of China [91027045, 21273250, 21021003]
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Bioluminescent microcapsules uploading D-luciferin have been fabricated by using the covalent assembly of firefly luciferase and alginate dialdehyde through a layer-by-layer technique. Such assembled microcapsules can produce visible light in the region of 520680nm, which can activate the photosensitizers rose bengal (RB) and hypocrellin B (HB) after adding ATP. The microcapsules uploading photosensitizers (RB or HB) have an obvious property to prevent the proliferation of tumor cells in the dark. The assembled bioluminescent microcapsules can be potentially used as photon donors for bioimaging, ATP detection, and photodynamic therapy.
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