4.6 Article

Glycosylated Nanoscale Surfaces: Preparation and Applications in Medicine and Molecular Biology

Journal

CHEMISTRY-A EUROPEAN JOURNAL
Volume 19, Issue 12, Pages 3794-3800

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201204155

Keywords

carbohydrates; molecular biology; multivalency; nanomaterials; surface chemistry

Funding

  1. Max Planck Society
  2. European Union FP7 (IIF)
  3. European Union FP7 (CARMUSYS)

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Carbohydrates on cell surfaces are critical components of the extracellular landscape and contribute to cell signalling, motility, adhesion and recognition. Multivalent effects are essential to these interactions that are inherently weak. Carbohydrate-functionalised surfaces meet an important need for studying the multivalent interactions between carbohydrates and other biomolecules. Innovations in nanomaterials are revolutionising how these carbohydrate interfaces are studied and underscore their importance in the cosmos of biochemical interactions.

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