Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 19, Issue 24, Pages 7917-7930Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201300696
Keywords
batch processes; flow chemistry; medicinal chemistry; organic chemistry; synthetic methods
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Funding
- Pfizer
- Commonwealth Scholarship Commission
- EPSRC
- BP 1702 endowment
- Royal Society
- EPSRC [EP/F069685/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/F069685/1] Funding Source: researchfish
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Here we report the direct comparison of a conventional batch mode synthesis of Meclinertant (SR48692, 1), a neurotensin receptor-1 antagonist, with its machine-assisted flow chemistry alternative. By using these enabling tools, combined with solid-supported reagents and scavengers, many process advantages were observed. Care, however, must be taken not to convert these techniques into expensive solutions to problems that do not exist.
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